Abstract 12680: Analysis of the Impact of Cardiovascular Disease on the Early Post-COVID Period Based on the ACTIV SARS-CoV-2 International Registry

Introduction: Cardiovascular disease (CVD) is a leading cause of mortality worldwide. The early post-hospitalization period following COVID-19 infection is critical due to high incidences of rehospitalization and deaths.

Aim: To study the impact of CVD on the first 3 months after hospitalization for COVID-19.

Methods: An international registry "ACTIV SARS-CoV-2" (NCT04492384) was established to characterize the course of COVID-19 in the Eurasian region and included 7 countries. The presented subanalysis used data of patients hospitalized during the acute phase of COVID-19. The post-COVID period was assessed based on telephone surveys of the patients 3 months (n=3099) after recovery.

Results: 79.8% of patients required unscheduled medical care in the first three months post-recovery from SARS-CoV-2 infection, with 11.8% necessitating rehospitalization. Decompensation of various CVDs was the most common reason for unscheduled medical care (Table 1).

The presence of CVD in people who had COVID-19, significantly increased the likelihood of death in the first 3 months after discharge from the infectious diseases hospital (OR 4.93; 95% CI 2.53-10.8; p<0.001).

The predominant causes of death were cardiovascular events, such as acute heart failure (22.4%; n=13), acute coronary syndrome (10.3%; n=6), acute cerebrovascular accident (10.3%; n=6), pulmonary embolism (3.4%; n=2), in addition to end-stage chronic kidney disease (5.2%; n=3).

Conclusions: Analysis of data from the "ACTIV SARS-CoV-2" registry showed that CVD may be a risk factor for a more severe course of the early post-COVID period. Moreover, cardiovascular conditions were the leading cause of unscheduled healthcare encounters and death in the first 3 months after recovery from COVID-19, which may underscore the contribution of this infection to decompensation of CVD.