DOI: 10.1161/circ.148.suppl_1.12256 ISSN: 0009-7322

Abstract 12256: The High FIB-4 Index is Independently Associated With an Increased Myocardial Extracellular Volume Fraction Quantified by Contrast-Enhanced Cardiac Magnetic Resonance Imaging

Hiroyuki Miura, Masahiro Koseki, Seiko Ide, kazuhiro nakao, Yasuhide Asaumi, Yoshiaki Morita, Yasutoshi Ohta, Tetsuya Fukuda, Katsunao Tanaka, Takashi Omatsu, Takeshi Okada, Teruo Noguchi, Yasushi Sakata
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Introduction: Liver fibrosis is associated with heart failure and left ventricular diastolic dysfunction. The fibrosis 4 (FIB-4) index is calculated from transaminases, age, and platelet count and can be used to screen patients with liver fibrosis. The myocardial extracellular volume fraction (ECVf) can be evaluated using contrast-enhanced cardiac magnetic resonance imaging (CMR).

Hypothesis: ECVf is increased in patients with high FIB-4 index. AIMS: This study aimed to clarify the association between FIB-4 index and ECVf.

Methods: A retrospective analysis was performed on patients aged ≥ 45 years with left ventricular ejection fraction (LVEF) > 40 % who underwent CMR at two Japanese institutions. Patients were divided into 3 groups according to the FIB-4 index: Low: FIB-4 index < 1.3; Intermediate: 1.3 ≤ FIB-4 index < 2.67; High: 2.67 ≤ FIB-4 index. The association between the FIB-4 index and ECVf was evaluated using multiple regression analysis, with the FIB-4 index treated as a continuous and nominal variable.

Results: A total of 244 patients were included in the analysis, 136 of whom underwent contrast-enhanced CMR and could be evaluated for ECVf. The ECVf of the high FIB-4 index group was significantly higher than that of the other two groups (High: 31.0 ± 4.3 %; Intermediate: 27.9 ± 3.4 %; Low: 27.6 ± 3.7 %. High vs. Intermediate, p = 0.014; High vs. Low, p = 0.008; Intermediate vs. Low, p = 0.65). Multivariate analysis showed that both the FIB-4 index (continuous variable) and high FIB-4 index (nominal variable) were associated with higher ECVf (continuous variable, p = 0.043; nominal variable, p = 0.016).

Conclusions: The high FIB-4 index was independently associated with increased ECVf. In contrast, patients with the intermediate FIB-4 index did not have increased ECVf. These suggested the usefulness of FIB-4 index as a cardiac fibrotic parameter.

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