Abstract 11799: Sex Disparities in Characteristics and Outcomes in Patients Admitted With Takayasu Arteritis

Introduction: Takayasu Arteritis (TA) is a rare form of chronic and progressive granulomatous vasculitis, mainly affecting the aorta and its branches. It is known to be more prevalent in young females of childbearing age. Our study compares potential disparities between Males and Females with TA.

Methods: Our study focused on patients diagnosed with TA admitted between 2016-2020 via the National Inpatient Sample. We compared the prevalence of different comorbidities between Males and Females . Logistic models allowed us to evaluate any differences between outcomes between the two groups.

Results: We found 7210 patients with TA in the United States, comprising 1575 (21.8%) males and 5635(78.2%) females. Females were older (mean age 45.67 years) than Males( mean age 43.29 years, p<0.01), but with a lower mean Charlson Comorbidity Index (CCI) score (2.45 in females and 2.75 in males, p<0.01). Considerable differences in patient characteristics were also observed, as described in Table 1. Overall Males were also more likely than females to report events of aortic aneurysms (aOR 1.959, 95% CI 1.607-2.389, p<0.01), aortic dissections (aOR 3.147, 95% CI 2.337-4.238, p<0.01), acute kidney injury (AKI) (aOR 1.589, 95% CI 1.344-1.879, p<0.01), acute limb ischemia (aOR 1.896, 95% CI 1.138-3.160, p=0.014), and death (aOR 1.381, 95% CI 1.012-1.883, p=0.042). However, no differences were noted in events of major adverse cardiac events (MACE) (aOR 1.028, 95% CI 0.838-1.257, p=0.807).

Conclusions: Males had less prevalence of TA than Females but still reported a higher likelihood of complications of aortitis, i.e., Aortic aneurysms as well as dissection. The greater incidence of AKI in males may be linked to direct insult to the vessels or secondary to their comorbidities. Even though no differences in MACE were seen between the two sexes, male patients had higher mortality.