Abstract 11686: Aortic Stenosis is Independently Associated With Smoking, Diabetes Mellitus, Hypertension, Hyperlipidemia, Renal Disease, COPD, and Caucasian Ethnicity in Addition to Advanced Age, Rheumatic Fever, and Bicuspid Aortic Valve

Hypothesis: Aortic valve stenosis is known to be associated with age, rheumatic fever, and bicuspid aortic valve but its association with other cardiovascular risk factors is less known. The purpose of this study was to investigate any association between aortic stenosis and other common cardiovascular risk factors.

Method: The large Nationwide Inpatient Sample database was utilized to study these associations using uni- and multivariate analyses. Data was extracted from the first available database that used ICD-10 codes specifically coding aortic stenosis alone, which occurred in the year 2016.

Results: In the database of patients over age of 40, a significant association was identified between aortic stenosis and smoking (OR: 1.12, CI 1.1 - 1.15, P < 0.001), diabetes mellitus (OR: 1.19, CI 1.17 - 1.21, P < 0.001), hypertension (OR: 1.36, CI 1.33 - 1.39, P < 0.001), hyperlipidemia (OR: 1.47, CI 1.44 - 1.49, P < 0.001), renal disease (OR: 1.46, CI 1.43 - 1.48, P < 0.001), chronic obstructive lung disease (COPD) (OR: 1.16, CI 1.14 - 1.18, P < 0.001), obesity (OR: 1.35, CI 1.32 - 1.39, P < 0.001), and Caucasian race (OR: 1.47, CI 1.42 - 1.52, P < 0.001), in addition to known factors such as age, rheumatic disease and bicuspid aortic valve.

Conclusion: Based on this large database study, we found a new association of aortic valve stenosis with race and many cardiovascular risk factors such as smoking, renal disease, COPD, Caucasian race, and obesity. The role of these new risk factors in the pathogenesis of aortic stenosis warrants further investigation.