DOI: 10.1161/circ.148.suppl_1.11631 ISSN: 0009-7322

Abstract 11631: Subclinical Atherosclerosis Risk of Isolated Diastolic Hypertension in Young Adults

Jindong Wan, Sen Liu, Yi Yang, Xinquan Wang, Peng Zhou, Peijian Wang
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Aim: Hypertension among young adults is common. Little is known regarding subclinical atherosclerosis development associated with isolated diastolic hypertension (IDH) among young adults. This study aimed to assess the relationship between IDH and some surrogate markers of subclinical atherosclerosis in young adults.

Methods: From January 2018 to December 2022, we consecutively enrolled 576 IDH individuals (aged 18 to 39 years) without cardiovascular complications and 576 normotensive subjects matched for age, sex and body mass index (BMI). Each participant underwent anthropometric measurements, serum biochemistry evaluation, 24-h ambulatory blood pressure (BP) monitoring, echocardiography, and carotid ultrasonography. Surrogate markers of subclinical atherosclerosis included carotid intima-media thickness (cIMT), ankle-brachial index (ABI), coronary calcification, and biochemical parameters. IDH was defined as diastolic BP ≥ 90 mmHg and systolic BP < 140 mmHg.

Results: Individuals with IDH had higher cIMT, greater ABI, and a higher frequency of coronary calcification and albuminuria (all P < 0.05). IDH was correlated with cIMT, ABI, coronary calcification, and albuminuria (Pearson’s correlation coefficients: 0.471, 0.365, 0.411, and 0.268, respectively; all P < 0.05). Compared with normotensive individuals, IDH was related to odds ratios of 2.09 (95% confidence interval [CI], 1.21-3.16), 2.72 (95% CI, 1.52-4.56), 1.78 (95% CI,1.15-2.89), and 1.26 (95% CI, 0.48-2.05) for cIMT, ABI, coronary calcification, and albuminuria, respectively.

Conclusion: Our findings emphasize the importance of assessing IDH in young adults to identify high-risk individuals for preventing subclinical atherosclerosis complications.

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