Abstract 11513: Impact of Pulmonary Hypertension on Patients With Heart Failure With Preserved Ejection Fraction: A 5-year Analysis

Introduction: The purpose of this retrospective study is to determine the impact of pulmonary hypertension on the outcome of patients with heart failure with preserved ejection fraction (HFpEF). The study investigated various outcomes associated with pulmonary hypertension in HFpEF patients.

Methods: We analyzed data from the National Inpatient Sample between 2016 and 2020 to identify patients admitted to the hospital with an acute exacerbation of HFpEF and pulmonary hypertension as a secondary diagnosis. This retrospective study used multivariable logistic and linear regression analysis to identify factors associated with mortality, hospital length of stay, total charges, and other secondary outcomes. Outcomes were adjusted to multiple factors including age, race, gender, and other comorbidities.

Results: 343,490 patients were admitted with an acute exacerbation of HFpEF from 2016 to 2020, of whom 127,655 also carried the diagnosis of pulmonary hypertension. Patients with pulmonary hypertension were at higher risk for mortality, longer hospital stay, and incurred greater healthcare costs. Additionally, patients with pulmonary hypertension were at increased risk of atrial fibrillation, ventricular tachycardia, and ventricular fibrillation. Despite no difference in the rate of developing acute respiratory failure between both groups, patients with pulmonary hypertension were more likely to need non-invasive ventilation or mechanical ventilation.

Conclusions: The study concludes that the presence of pulmonary hypertension in HFpEF patients is linked to poorer outcomes, including increased mortality risk, longer hospital stay, higher healthcare costs, and greater risk for complications such as arrhythmias and ventilation requirements. Early identification and management of pulmonary hypertension are important to improve patient outcomes, Nevertheless, more research is needed to determine the most effective treatment approaches.