DOI: 10.1093/ofid/ofag510 ISSN: 2328-8957

Absence of Mycoplasma genitalium Strains Simultaneously Harboring Wild-Type gyrA , parC , and 23S rRNA Genes

Ayane Nishino, Natsumi Haba, Seiya Sawada, Kosuke Mizutani, Koji Kameyama, Shingo Kamei, Shigeaki Yokoi, Satoshi Ishihara, Masaki Takanashi, Yoshihisa Ashihara, Yuji Sekiguchi, Shin Ito, Mitsuru Yasuda, Takashi Deguchi
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Abstract

Using next-generation sequencing, we analyzed fluoroquinolone and macrolide resistance-associated mutations of the gyrA, parC, and 23S rRNA genes in Mycoplasma genitalium and detected mutations in 22.3% (37/166), 92.5% (161/174), and 96.0% (169/176), respectively, in Japan. No strains harboring three wild-type genes were identified, indicating widespread dissemination of antimicrobial resistance.

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