Nobuhiro Takahashi, Mototoshi Kato, Yohei Yamada, Hanako Tsujikawa, Rie Irie, Koji Okabayashi, Yuko Kitagawa, Tatsuo Kuroda

Abnormal distribution of fat tissue and its association with intestinal failure–associated liver disease in children and adolescents with long‐time parenteral nutrition support: A case‐control study

  • Nutrition and Dietetics
  • Medicine (miscellaneous)
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AbstractBackgroundPatients with intestinal failure (IF) often present with abnormal body composition characterized by high fat mass. However, the distribution of fat and its association with the development of IF‐associated liver disease (IFALD) remain unclear. This study aims to investigate the body composition and its relationship with IFALD in older children and adolescents with IF.MethodsThis retrospective case‐control study enrolled patients with IF receiving parenteral nutrition (PN) at Keio University Hospital who initiated PN before the age of 20 years (cases). The control group included patients with abdominal pain, with available computed tomography (CT) scan and anthropometric data. CT scan images of the third lumbar vertebra (L3) were used for body composition analysis and compared between the groups. Liver histology was compared with CT scan findings in IF patients who underwent biopsy.ResultsNineteen IF patients and 124 control patients were included. To account for age distribution, 51 control patients were selected. The median skeletal muscle index was 33.9 (29.1–37.3) in the IF group and 42.1 (39.1–45.7) in the control group (P < 0.01). The median visceral adipose tissue index (VATI) was 9.6 (4.9–21.0) in the IF group and 4.6 (3.0–8.3) in the control group (P = 0.018). Among the 13 patients with IF who underwent liver biopsies, 11 (84.6%) had steatosis, and there was a tendency for fibrosis to correlate with VATI.ConclusionPatients with IF exhibit low skeletal muscle mass and high visceral fat, which may be related to liver fibrosis. Routine monitoring of body composition is recommended.

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