A75-10 A National Inpatient Analysis of Mortality Rates of Ischemic Stroke Patients With Cystic Fibrosis

Rationale

Patients with cystic fibrosis (CF) are known to be at higher risk of acute ischemic stroke than the general population. As life expectancy of CF patients has increased in the 20th century, there exists limited data in this population regarding common hospitalization causes that are seen in adults across the U.S such as stroke. This study attempts to bridge the gap in this deficit to assess stroke as a significant cause of mortality in the CF population, more so than the general population.

Methods

A retrospective analysis was conducted using NIS data from 2016-2022, identifying CF patients hospitalized for acute ischemic stroke by discharge ICD-10 codes. The rate of inpatient mortality was calculated. Multivariate logistic regression was used to identify associations between baseline characteristics (age, sex, race, income) and comorbidities (atrial fibrillation, hypertension, smoking status, peripheral vascular disease, diabetes, chronic kidney disease, heart failure, COPD, and coronary artery disease) with mortality.

Results

From 2016-2022, there were 121,340 hospitalizations with CF. 1,995 died during hospitalization. Of these, 300 were hospitalized for ischemic stroke, which represents only 0.25% of CF hospitalizations. Of these 300 hospitalizations, 70 had died which represents 23% of hospitalizations and 3.5% of all CF inpatient mortalities. The adjusted odds-ratio (aOR) for mortality from stroke in the CF population was calculated to be 3.97 (p < 0.05) as compared to mortality from stroke in the general population. Predictors of mortality included age over 65 years, Black (aOR 1.84) or Hispanic (aOR 1.96) race, and history of heart failure (aOR 1.9).

Conclusions

CF patients are known to be at increased risk of ischemic stroke. While hospitalizations for stroke in this population were sparse, they were calculated to be almost 4 times as likely to die during hospitalization than the general population. Age over 65 years, Black and Hispanic race, and history of heart failure were associated with poor prognosis. Clinical Implications:Life expectancy of CF patients has increased from 6 months to 42.7 years. As such, we find ourselves in an era when this population is developing common comorbidities of the general population. The disproportionate increase in risk of mortality from stroke compared to the general population suggests that CF patients who are high-risk should be identified early. Further studies should be conducted regarding primary prevention for ischemic stroke in these patients.

This abstract is funded by: None