A Transparent and Injectable Biomaterial Prepared by Mixing Collagen and Anti‐Cancer Platinum Derivatives

Abstract

This study presents the synthesis of a cross‐linked collagen material, named platinum‐containing collagen gel (PCG), which is achieved by simply mixing collagen and derivatives of an anti‐cancer platinum complex. The cross‐linking reagents are derivatives of cisplatin or transplatin, generated through a ligand exchange with dimethyl sulfoxide. PCG exhibits superior physical strength and transparency compared with the native collagen gel formed through spontaneous fibril formation. The versatility of PCG as a cell culture scaffold, applicable to both 2D and 3D models, with low cytotoxicity is demonstrated. Furthermore, PCG exhibits pH‐responsive gel‐forming properties. This enables the removal of free cross‐linker by dialysis in an acidic solution and subsequent gel formation upon neutralization. This material holds promise for application in cell culture scaffolds and medical injections.