A TEN YEARS RETROSPECTIVE EVALUATION OF CLINICAL AND TREATMENT OUTCOME OF CARCINOMA BREAST

Background: Breast cancer most often begins with cells in the milk-producing ducts (invasive ductal carcinoma). Breast cancer may also begin in the glandular tissue called lobules (invasive lobular carcinoma) or in other cells or tissue within the breast. Breast cancer is the most common cancer in women overall. Globally, breast cancer now represents one in four of all cancers in women. This study is the evaluation OF CLINICAL AND TREATMENT OUTCOME OF CARCINOMA BREAST" on the basis of patient's characteristic distribution, disease characteristics, management and follow up. Aims And Objective- The aim of this study is to evaluate patient's characteristic distribution, disease characteristics, management and follow up. The objective of this study is retrospective evaluation of all patients with carcinoma breast registered in Radiation Oncology Department at GMC, Bhopal in last ten years. Material And Method- This retrospective analytical study was included 1061 patients of breast cancer registered at Department of Radiation Oncology, Gandhi Medical College and Hamidia Hospital Bhopal in last ten years from 2010 to 2019. Data would include total number of patients of carcinoma breast registered; proportion of breast cancer cases treated by chemotherapy and radiotherapy. Patient details: Name, age, sex, Hormonal receptor status , Histopathology details and TNM stage with stage group , Menstrual status 5) Family history , Treatment strategy, details of treatment and compliance to treatment , Response to treatment using RECIST criteria , Details of follow up at 3 month, 6 months,1 year . Treatment outcome in terms of no abnormality detected, relapse, recurrence or residual disease. Result – Average age was observed to be 47.36 years with SD of 11.66. Maximum number of the patients presented with IIIA stage( 44.2% ), maximum number of patients were having IDC (inlterating ductal carcinoma ) or IVC ( invasive ductal carcinoma ) ( 84.07 %) . The hormonal receptors ER receptors were observed in majority of the patients with 38.54 % , Only 3.01% patients having signicant family history ,majority of patients 56.83 % were belonging to premenopausal group. Nearly 154 patients were having metastasis at various sites out of which 62.9% Bone metastasis followed by 24.6% lung metastasis . Maximum number of patients were treated with Chemotherapy (84.8%) followed by surgery with nearly ( 76.3 %) of the patients. Patients were treated as hormonal therapy with majority of Letrozole 27.5% , followed by Anastrazole 7.06% Average of 699.3 with SD of 169.99 patients have been followed up for the mean time period of 6 months , and nearly 18.57 % patients showed the negative response in follow up. Majority of the patients were observed in PR with 46.5 % volume. Conclusion- Breast cancer is the most common malignancies prevalent in India in female and are major public health burden. Incidence of breast cancer are increasing because of lack of awareness, increasing with age. Majority of the patients present at locally advanced stage hence neoadjuvant chemotherapy plays an important role in downstaging the tumour. Standard follow-up of patients treated for breast cancer is based on regular follow-up visits, with frequency decreasing in consecutive years.