Melody Baruah, Himadri Dutta, Deep Jyoti Kalita

A SURGE OF H3N2 INFLUENZA CASES IN PATIENTS PRESENTING WITH FLU-LIKE SYMPTOMS: AN EXPERIENCE FROM A TERTIARY CARE HOSPITAL

  • General Medicine
  • General Earth and Planetary Sciences
  • General Environmental Science
  • General Medicine
  • Ocean Engineering
  • General Medicine
  • General Medicine
  • General Medicine
  • General Medicine
  • General Earth and Planetary Sciences
  • General Environmental Science
  • General Medicine
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Introduction: Seasonal inuenza remains a considerable cause of excess morbidity, mortality, and healthcare-system burden. Over the time, many variants of inuenza viruses have evolved and created panic situations, especially in the vulnerable population. Present study was conducted to observe the epidemiological pro Aims and objectives: le, clinical presentations, associated comorbidities, laboratory parameters and outcome of the patients presenting with respiratory symptoms following a surge of Inuenza A cases in a tertiary care super specialty hospital of North East India. This observational retrospective study Materials and Methods: was done during the period of March 2023 to August 2023. All the suspected cases for inuenza like illness attending our hospital and tested for SarsCoV -2, H1N1 and H3N2 were included. Viral nucleic acid was extracted and detection was done using Truenat COVID-19 and Trunat (H1N1+H3N2 combo) micro PCR assay. The epidemiological data, clinical prole, co-morbidities, laboratory parameters and outcome of these patients were recorded and statistical analysis was done using Chi square and Z test for obtaining p value. A total of 350 cases were Results: included in the study. 66 conrmed cases of Inuenza A (3 H1N1 and 63 H3N2) were detected during the study period and none tested positive for COVID-19. Majority of patients belonged to the age group of >60 years. Both genders were equally affected with slight male preponderance. 15 patients required Intensive Care Unit (ICU) admission while 15 patients were managed in ward. The predominant symptoms at presentation were fever (84.57%), cough (46.28%) and Rhinitis (42.8%). Most common comorbid conditions associated were diabetes mellitus (10.28%), hypertension (7.42%), coronary artery disease (4.86%) and chronic obstructive pulmonary disease (COPD) (3.42%). : From this Conclusion study, it can be hypothesized that the prevalence of Inuenza A H3N2 is high in the elderly population, and is more common during the monsoon season with most patients presenting with symptoms resembling u. Vaccination, early recognition of the disease, and prompt initiation of treatment seem to be the only way to reduce the disease progression and associated mortality. TruenatPCR helps in the rapid and early diagnosis of Inuenza A cases.

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