A STUDY TO DETERMINE ASSOCIATION OF SERUM HOMOCYSTEINE LEVELS IN DIABETES MELLITUS TYPE 2 AND CARDIOVASCULAR DISEASES WITH HYPERTENSION AND CORONARY ARTERY DISEASE.

Background and Objectives: The increased prevalence of elevated homocysteine levels is noted in subjects of Type-2 diabetes (T2D) with macroangiopathy and nephropathy. As hyperhomocysteinemia, with treatment is a modiable risk factor, correction of hyperhomocysteinemia may have a benecial effect in T2D. The aims of the study were 1) to study the role of homocysteine in T2D and CVD and 2) to study the role of factors that alter the level of homocysteine. A retrospective cross-secti Method: onal study was conducted on 100 subjects in tertiary care centre in Western India. Anthropometry, demography and biochemistry data were collected using standard protocol. Statistical analysis was done using chisquare test. P value of <0.05 was considered signicant. We report signicantly Result: higher proportion of hyperhomocysteinemia in male gender, smokers and subjects with high random blood sugar level. Proportion of subjects with elevated homocysteine levels was signicantly higher in subjects with high LDL and high triglyceride levels. Signicant association of raised serum homocysteine levels and reduced vitamin B12 levels was noted in patients with ischemic heart disease. Hyperhomocys Conclusion: teinemia is associated with development of T2D and cardiovascular diseases. Vitamin B12 deciency contribute to hyperhomocysteinemia.