A Review of Thiazolidinones: Versatile Heterocycles with Promising Therapeutic Potential

Thiazolidinones are multifaceted compounds with considerable pharmacological potential owing to their chemical structure, which permits alterations such as ring substitution and functionalization. They demonstrate diverse pharmacological actions, encompassing antibacterial, anticancer, anti-inflammatory, antidiabetic, and neuroprotective properties. They engage with targets such as PPAR-γ, NF-κB, COX enzymes, and DNA topoisomerases. Thiazolidinediones are recognized for their insulin-sensitizing effects, functioning as PPAR-γ agonists in the management of type 2 diabetes. Improvements in formulation strategies increase its bioavailability and effectiveness. Future research should concentrate on individualized therapy, sophisticated delivery systems, and synergistic combinations with additional medicinal medicines.