A Review of Analytical Methods for Clopidogrel Bisulfate

The main purpose of the frequently prescribed antiplatelet drug clopidogrel bisulfate is to protect patients with atherosclerosis and acute coronary syndromes from cardiovascular events. Clopidogrel bisulfate analysis must be accurate and trustworthy for clinical research and pharmaceutical quality control. The study thoroughly examines analytical methods, including spectroscopic, bioanalytical, and chromatographic approaches. Each method's benefits, drawbacks, and applications are discussed, offering helpful insights into how well they work for various analytical goals. Due to their excellent sensitivity, selectivity, and precision, chromatographic methods like high-performance liquid chromatography (HPLC) have been the most widely used technique for clopidogrel bisulfate analysis. The creation of various stationary phases and mobile phases has improved separation efficiency and increased the precision of drug quantification. Clopidogrel bisulfate has been extensively determined in pharmaceutical formulations and biological samples using spectroscopic techniques, such as UV-visible spectrophotometry, infrared spectroscopy (IR), and nuclear magnetic resonance (NMR) spectroscopy. These techniques provide quick analysis and straightforward sample preparation steps. Bioanalytical plans, including substance-causing chemicals to split into simpler substances-linked immunosorbent assays (ELISA) and liquid chromatography-bulk spectrometry (LC-MS), are necessary for the measurement of clopidogrel bisulfate in organic casts, such as red body fluid or excretion, in pharmacokinetic and bioequivalence studies. The variety of examining methods debated in this place will aid in selecting the ultimate appropriate method for specific examining necessities, eventually providing the safe and productive use of clopidogrel bisulfate in dispassionate practice.