A review article on the sweet scandal: The truth behind rhodamine B

Cotton candy is a popular treat with various names around the world. It debuted toward the end of the 1800s at the St. Louis World’s Fair. Different names for it were used in distinct parts of the world. Rhodamine B (Rh-B), a basic dye developed in 1887, serves diverse industrial purposes. During the metabolism of Rh-B, cytochrome 450 breaks down, generating oxidative stress and reactive oxygen species. It should be cautiously used due to its possible mutagenic qualities and negative effects on cellular function, including binding to DNA. The article examines the physical and chemical characteristics of Rh-B and its applications, mechanisms, and impacts on brain function, particularly in the cerebellum and brainstem. Studies suggest that exposure to Rh-B may result in functional abnormalities and mutagenic effects. In this review, Rh-B poses significant risks to human health and the environment, necessitating careful consideration and regulatory measures in its usage and disposal.