DOI: 10.1097/inf.0000000000004215 ISSN: 0891-3668

A Rare Case of COVID-19 Related Acute Necrotizing Encephalopathy With the RANBP2 Mutation in a Pediatric Patient

Evangelos Christou, Alkisti Kotsia, Konstantinos Tziouvas, Panagiotis Filias, Aristoula Patsoura
  • Infectious Diseases
  • Microbiology (medical)
  • Pediatrics, Perinatology and Child Health
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Acute necrotizing encephalopathy (ANE) is a rare childhood neurological disorder. The familiar type of ANE (ANE1) is associated with a mutation in the RANBP2 gene. Both SARS-CoV-2 and RANBP2 mutations are responsible for the manifestation of a hyper-inflammatory response that invades the central nervous system and plays a key role in the rapid progression of encephalopathy.

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