A randomized controlled trial investigating the effect of spermidine-enriched dietary supplementation on fertility-related outcomes and sleep quality in men with spermatogenic failure
Dewei Qian, Beifen Zhong, Peng Li, Chencheng Yao, Erlei Zhi, Huirong Chen, Fujun Zhao, Zheng Li, Ruhui TianBackground:
Male infertility accounts for nearly half of all infertility cases and profoundly affects psychological well-being and quality of life. Spermidine, a naturally occurring polyamine with autophagy-promoting and antiaging effects, has been associated with improved sleep and emotional health. However, its effect on fertility-related quality of life in men with spermatogenic failure (SPGF) remains unknown. This study aimed to investigate the effects of spermidine-enriched dietary supplementation on fertility-related quality of life and sleep quality in men with SPGF and to assess its safety.
Materials and methods:
In this randomized, double-blind, placebo-controlled trial (registration No.: ChiCTR2300077972), 60 men with SPGF were assigned (1:1) to receive spermidine (4 mg/d) or placebo for 3 months alongside standard therapy. Primary outcomes were changes in Fertility Quality of Life and Pittsburgh Sleep Quality Index. Secondary and exploratory outcomes included semen parameters, hepatic and renal safety markers, and sex hormone levels.
Results:
Among 60 randomized participants, spermidine supplementation significantly improved Fertility Quality of Life (adjusted
Conclusions:
Spermidine supplementation improved fertility-related quality of life and sleep quality in men with SPGF and was well tolerated. These findings support its potential as a noninvasive adjunct to enhance well-being in male infertility.