DOI: 10.1039/d3sc05766f ISSN: 2041-6520
A pyridinium-based strategy for lysine-selective protein modification and chemoproteomic profiling in live cells
Chuan Wan, Dongyan Yang, Chunli Song, Mingchan Liang, Yuhao An, Chenshan Lian, Chuan Dai, Yuxin Ye, Feng Yin, Rui Wang, Zigang Li- General Chemistry
The utilization of the cationic-pyridinium activated ester strategy facilitates the chemoselective labeling of lysine residues within proteins, enabling activity-based protein profiling (ABPP) both in vitro and in live cells.