A Prospective Study On Serum D–Dimer Level At The Admission For Prediction Of Severity Of Acute Pancreatitis

Background: Acute pancreatitis is an inammatory condition with a variable clinical course, ranging from mild to severe forms that can lead to signicant morbidity and mortality. Early prediction of disease severity is crucial for appropriate management. Serum D-dimer, a brin degradation product, may serve as a predictive biomarker for the severity of acute pancreatitis due to its association with coagulation and inammatory processes. Methods: This prospective observational study was conducted at the General Surgery department of Victoria Hospital, BMCRI, Bengaluru, from April 2024 to July 2024. A total of 60 patients diagnosed with acute pancreatitis and admitted within 24 hours of symptom onset were enrolled. Serum D-dimer levels were measured at admission, day 3 and 5. Patients were assessed for complications, including acute pancreatic uid collection, acute necrotic collection, organ failure, pancreatic necrosis, and persistent organ failure. Statistical analysis was performed using SPSS version 22, with a p-value of <0.05 considered signicant. Results: The mean serum D-dimer levels were signicantly higher in patients with severe complications such as pancreatic necrosis and persistent organ failure compared to those with no complications . A signicant correlation was found between elevated D-dimer levels and the severity of complications, with the highest levels observed in patients with pancreatic necrosis. Age and sex did not signicantly inuence the occurrence of complications. The study ndings suggest that serum Ddimer levels at admission are a reliable predictor of the severity of acute pancreatitis. Conclusion: Serum D-dimer levels at admission are signicantly associated with the severity of acute pancreatitis and may serve as a valuable prognostic marker for early identication of patients at risk for severe complications. Incorporating D-dimer testing into the initial assessment could improve clinical management and patient outcomes.