M. Suchitra, K. Krishnapriya, P. Ashalatha, K. Pradeep Kumar

A PROSPECTIVE RANDOMIZED STUDY TO COMPARE THE EFFICACY AND SAFETY OF 0.5% LEVOBUPIVACAINE WITH 0.5% BUPIVACAINE IN SPINAL ANAESTHESIA ON PATIENTS UNDERGOING TOTAL KNEE ARTHROPLASTY

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Background:Total knee Arthroplasty(TKA) surgery is a major surgical procedure that requires effective and safe anaesthesia. Spinal anaesthesia is most widely used technique for total knee arthroplasty surgeries. Choice of local anaesthetics depends mainly onset, duration, intensity of sensory and motor block and side effects. Aim: To study and compare the efcacy and safety of 0.5% Levobupivacaine with 0.5% Bupivacaine in spinal anaesthesia on patients undergoing total knee replacement surgery . Design: Randomised Controlled study. Material & Methods: The study includes 40 patients randomly divided into 2 groups of 20 each. Group A patients received 3ml of 0.5% Levobupivacaine (15mg) 5mg/ml with 15 mcg of fentanyl.Group B patients received 3ml of 0.5% Bupivacaine (15mg) 5mg/ml with 15 mcg of fentanyl. Statistical Analysis: by using SPSS version 20 (Statistical Package for Social Studies), Chi square test, F table, Mean and standard deviation were used. Results & Conclusion: Duration of sensory block and time for rst requirement of post-operative analgesia was longer in patients who received 0.5% Levobupivacaine intrathecally when compared to 0.5% Bupivacaine intrathecally. Though there was no statistical signicance in terms of onset of sensory block, there was a slow onset of motor block and less duration of motor block seen in Levobupivacaine group. Stable haemodynamics were observed with Levobupicaine. Hence, Levobupivacaine is a better alternative to Bupivacaine.

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