DOI: 10.4103/cdr.cdr_86_21 ISSN:

A Prospective Comparative Study of Efficacy of Intralesional Bleomycin Injection with Intralesional 5-FU Injection in Resistant Palmo-Plantar Warts

Prasoon Sachan, Santosh Kumar Singh, Amit Kumar Pandey, Anil Kumar Gupta, Raj Kumar
  • General Materials Science


Treating of recalcitrant viral verrucae either individually or in combination is inconvenient and frustrating both for patients and treating physician. There is no treatment, which is 100% effective for warts.


To compare the use of intralesional 5-flourouracil and intralesional bleomycin with respect to efficacy and side effects in treatment of recalcitrant palmo-plantar verrucae.

Materials and Methods:

A prospective comparative study was conducted toassess the eeficacy of intralesional bleomycin injection with intralesional 5-Fluoro Uracil (FU) in resistant palmo-plantar warts.


Intralesional bleomycin was found to be more efficacious than intralesional 5-FU in treatment of recalcitrant palmo-plantar warts however much more side effects were noted in intralesional bleomycin than intralesional 5-FU. None of the side-effects were found to be life threatening. Moreover 5-FU is cheaper and easily procurable than injection bleomycin.


Both intralesional bleomycin and 5-FU injections can be safely used in the treatment of recalcitrant palmo-plantar verrucae.

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