A Portable Electrical Response Verification System for Blood Glucose Meters Based on Dynamic Microcurrent Reproduction

Portable blood glucose meters are commonly evaluated using test strips and control solutions, which assess the combined meter–strip–reagent response but are not designed to provide a directly controlled, pre-characterized electrical stimulus for repeated meter-side verification. This study developed a portable electrical response verification system based on dynamic microcurrent reproduction using a calibrated programmable current source. At each of two control solution levels, five 1000-point test strip current responses were acquired. Each response was reduced to 100 points by averaging every 10 consecutive samples, and the five reduced responses were then averaged point by point to obtain one level-specific mean reference waveform. Each mean waveform was converted into a 100-point DAC code table for STM32-controlled reproduction. The current source provided a measured output range of 0.016–9.829 μA. Five repeated reproductions per level yielded mean Pearson correlation coefficients of 0.9993 and 0.9995 and peak current CV values of 2.52% and 1.59%, respectively. The corresponding GA-3 meter (Sinocare Inc., Changsha, Hunan, China) readings differed from the mean original readings by 1.70% and 1.18%, with CV values of 1.81% and 1.29%. These results support the feasibility of controlled electrical response verification and short-term repeatability assessment of strip-based blood glucose meters.