DOI: 10.1039/d5sc02476e ISSN: 2041-6520

A nuclear targeted type-I photosensitizer for anti-tumor therapy

Zipeng Li, Wenkai Liu, Wanying Ma, Changyu Zhang, Jiangli Fan, Xiaojun Peng

Se-PC, a novel nuclear DNA-targeted type I photosensitizer, exhibits strong DNA affinity and generates superoxide radicals under low-dose light, directly damaging DNA for potent tumor ablation, enhancing PDT efficacy.

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