A novel variant with a severe phenotype in CARD14-associated papulosquamous eruption successfully treated with ixekizumab

doi:10.1093/ced/llae019

Xiaoliang Ouyang, Deng Zhang, Xiuping Wang, Liang Wu, Zhen Xiao, Yunxia Zhu, Simin Yu, Chunming Li

A novel variant with a severe phenotype in CARD14-associated papulosquamous eruption successfully treated with ixekizumab

Dermatology

CARD14-associated papulosquamous eruption (CAPE) is an autosomal dominant disorder characterized by early onset of symptoms, prominent facial involvement, clinicalmanifestations resembling both psoriasis and pityriasis rubra pilaris(PRP), and limited response to conventional topical and systemic therapies for psoriasis or PRP. Here, we describe the clinical features of a patient with CAPE and a novel mutation of CARD14.

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A novel variant with a severe phenotype in CARD14-associated papulosquamous eruption successfully treated with ixekizumab

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