DOI: 10.1039/d4ra00202d ISSN: 2046-2069

A novel ultrasensitive chemiluminescence enzyme immunoassay by employment of a signal enhancement of horseradish peroxidase-luminol-hydrogen peroxide reaction for the quantitation of atezolizumab, a monoclonal antibody used for cancer immunotherapy

Ibrahim A. Darwish, Mohammad A. H. Ali, Mohammed S. Alsalhi, Daohong Zhang
  • General Chemical Engineering
  • General Chemistry

An ultrasensitive non-competitive chemiluminescence enzyme immunoassay (CLEIA) for the quantification of atezolizumab (ATZ), a monoclonal antibody used for treatment of different types of cancer. The assay employed a new chemiluminescence-enhancement reaction for detection.

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