A Novel Risk Score Model for the Differential Diagnosis of Type 2 Diabetic Nephropathy: A Multicenter Study
Yuetong Zhao, Lin Liu, Li Zuo, Xianghai Zhou, Song Wang, Hongwei Gao, Feng Yu, Xiaomei Zhang, Mi Wang, Ling Chen, Rui Zhang, Fang Zhang, Shuhong Bi, Qiong Bai, Jiaxiang Ding, Qinghua Yang, Sixu Xin, Sanbao Chai, Min Chen, Junqing Zhang- Endocrinology
- Endocrinology, Diabetes and Metabolism
Introduction. DN is a common complication of diabetes. However, diabetes combined with renal injury may involve DN or NDKD, with different treatment schemes. The purpose of our study was to determine the independent risk factors of DN and establish a risk score model to help differentiate DN and NDKD, providing a reference for clinical treatment. Methods. A total of 678 T2D patients who had undergone renal biopsy in four affiliated hospitals of Peking University were consecutively enrolled. Patients were assigned to the DN group and NDKD group according to histopathological results. Seventy percent of patients from PKUFH were randomly assigned to the training group, and the remaining 30% were assigned to the internal validation group. Patients from the other three centers were assigned to the external validation group. We used univariate and multivariate logistic regression analyses to identify independent risk factors of DN in the training group and conducted multivariate logistic regression analysis with these independent risk factors in the training group to find regression coefficients “