DOI: 10.1002/cnm.3799 ISSN: 2040-7939

A novel hypoglycemia alarm framework for type 2 diabetes with high glycemic variability

Xinzhuo Wang, Zi Yang, Ning Ma, Xiaoyu Sun, Hongru Li, Jian Zhou, Xia Yu
  • Applied Mathematics
  • Computational Theory and Mathematics
  • Molecular Biology
  • Modeling and Simulation
  • Biomedical Engineering
  • Software


In patients with type 2 diabetes (T2D), accurate prediction of hypoglycemic events is crucial for maintaining glycemic control and reducing their frequency. However, individuals with high blood glucose variability experience significant fluctuations over time, posing a challenge for early warning models that rely on static features. This article proposes a novel hypoglycemia early alarm framework based on dynamic feature selection. The framework incorporates domain knowledge and introduces multi‐scale blood glucose features, including predicted values, essential for early warnings. To address the complexity of the feature matrix, a dynamic feature selection mechanism (Relief‐SVM‐RFE) is designed to effectively eliminate redundancy. Furthermore, the framework employs online updates for the random forest model, enhancing the learning of more relevant features. The effectiveness of the framework was evaluated using a clinical dataset. For T2D patients with a high coefficient of variation (CV), the framework achieved a sensitivity of 81.15% and specificity of 98.14%, accurately predicting most hypoglycemic events. Notably, the proposed method outperformed other existing approaches. These results indicate the feasibility of anticipating hypoglycemic events in T2D patients with high CV using this innovative framework.

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