DOI: 10.1039/d3sc02350h ISSN:
A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease
Prayasee Baruah, Hariharan Moorthy, Madhu Ramesh, Dikshaa Padhi, Thimmaiah Govindaraju- General Chemistry
Tannic acid (TA) mitigates ferroptosis induced by amyloid β-Fe in Alzheimer's disease (AD) through a multipronged activity. TA activates and enhances the GPX4 levels to counteract the complex interaction between AD and ferroptosis.