DOI: 10.1039/d6ra08640c ISSN: 2046-2069
A molecular networking-guided strategy for identifying anti-osteoporotic sterols from the soft coral Sclerophytum humesi
Bo-Rong Peng, Yun-Shiuan Chen, Ting-Mei Wang, Phuong Vu Luu, Quoc-Vu Pham, Guan-Yi Lai, Hsin-Wei Wang, Lo-Yun Chen, Jui-Hsin Su, Kuei-Hung Lai, Huong-Giang Le, Ngoc-Thac Pham, Tuyet Nhung Tran, Mei-Hsien LeeBioactivity-guided fractionation integrated with LC-MS/MS-based molecular networking facilitated the discovery of osteogenic natural products from the soft coral Sclerophytum humesi , with anti-osteoporotic effects validated in a zebrafish model.