A Migrated Threat: Intravitreal Dexamethasone Implant in the Anterior Chamber with Contrasting Corneal Outcomes

Abstract

Intravitreal dexamethasone implant is widely used for treating retinal and inflammatory conditions but can rarely migrate into the anterior chamber, posing a threat to vision. We present two cases highlighting contrasting clinical outcomes following this complication in eyes with altered posterior segment anatomy—one managed successfully with repositioning and corneal recovery, and the other with persistent corneal decompensation requiring consideration of keratoplasty. Early recognition and prompt intervention are important to limit corneal injury and manage elevated intraocular pressure (IOP). Preventive strategies such as maintaining miosis in selected cases, although further evidence is needed, and careful patient selection may help minimize complications.