DOI: 10.1002/ijgo.15314 ISSN: 0020-7292

A long‐term retrospective analysis of management of cervical cancer during pregnancy

Xiaoyan Tang, Xuyin Zhang, Yan Ding, Yunqiang Zhang, Ning Zhang, Junjun Qiu, Keqin Hua
  • Obstetrics and Gynecology
  • General Medicine



This study aims to describe cervical cancer during pregnancy (CCP) and investigate factors associated with survival outcomes.


This retrospective matched study included CCP patients from May 2007 to August 2021 and matched non‐pregnant cervical cancer patients (1:2) based on age (±5 years), year at diagnosis (±2 years), histological type and stage (2018 FIGO). The Kaplan–Meier method and multivariate Cox regression analyses were used to assess the impact of pregnancy and clinicopathologic factors on prognosis.


Thirty‐eight CCP patients (stage IA to IIIC) and 76 non‐pregnant patients were included. Most CCP patients were diagnosed in the first (31.6%) or second (47.4%) trimester. CCP patients had a longer waiting time than non‐pregnant patients. Pregnancy continued in 42.1% (continuation of pregnancy [COP] group) and was terminated in 57.9% (termination of pregnancy [TOP] group) of patients. Survival analysis showed no significant differences in recurrence‐free survival (RFS) or overall survival (OS) between pregnant and non‐pregnant patients or between the COP and TOP groups. At the end of the follow‐up period (range 12–178 months), 23 children born to CCP patients exhibited normal development.


Pregnancy does not impact cervical cancer prognosis. The oncologic outcomes of the TOP and COP groups were comparable. A pregnancy‐preserving strategy could be considered for managing CCP patients.

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