A Living Archive of High-risk Lymphoma

Summary:

In this issue of Blood Cancer Discovery, Yang and colleagues present a comprehensive repository of patient-derived xenograft models of aggressive large B-cell lymphoma. The publicly available resource links disease specimens from individuals treated with diverse modern therapies (including chimeric antigen receptor T cells) to their high-risk clinical treatment histories and the molecular and transcriptional characteristics of their tumors, enabling the study of tumor cell–intrinsic mechanisms of therapeutic resistance and susceptibility to novel therapies.

See related article by Yang et al., p. XX .