DOI: 10.1039/d6lc00630b ISSN: 1473-0197
A human gut–BBB–brain microphysiological model for studying Alzheimer's disease
Yu-Shan Deng, Wan-Peng Wang, Fei Wang, Guo-Ming Ma, Jian-Feng Lin, Chen-Xi Yan, Yi-Ling Zhou, Lu-Yao Wang, Xue-Qi Gong, Li Sun, Jian Zhao, Gang Pei, Lin Zhang, Wen-Yuan WangAn iPSC-derived gut–BBB–brain microphysiological system enables controlled investigation of inter-organ communication. The platform reveals gut-associated molecular and AD-relevant responses in the brain compartment.