DOI: 10.1126/science.1080029 ISSN:

A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis

Jian Xu, Magnus K. Bjursell, Jason Himrod, Su Deng, Lynn K. Carmichael, Herbert C. Chiang, Lora V. Hooper, Jeffrey I. Gordon
  • Multidisciplinary

The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron , a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.

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