DOI: 10.1039/d3cc02771f ISSN:

A genetically encodable and fluorogenic photo-crosslinker via photo-induced defluorination acyl fluoride exchange

Jielin Fu, Sitong Li, Lijun Deng, Xiaohu Zhao, Zhipeng Yu
  • Materials Chemistry
  • Metals and Alloys
  • Surfaces, Coatings and Films
  • General Chemistry
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Catalysis

m-TFMAK was developed as a fluorogenic photo-crosslinker, incorporated into proteins via genetic code expansion in living cells. Photo-DAFEx of the encoded m-TFMAK allows proteomic tracking and visualization of protein–protein interactions.

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