Outline
DOI: 10.1039/d6qo01372d ISSN: 2052-4129
A difluorocarbene-activated dearomatization–rearomatization platform for late-stage C4-functionalization of the pyridine skeleton
Zheng-Wen Liang, Xingwei Xun, Xi-Cun Wang, Dong-Ping Chen, Zheng-Jun QuanThe study presents a difluorocarbene-activated method for highly regioselective 1,4-bifunctionalization and C4-functionalization of pyridine skeleton. The system operates without metal catalysts and is compatible with various nucleophilic reagents.
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