Background and Objectives- Melanocytes are derived from stem cell in the neural crest that normally migrate to the epidermis, where they are scattered along the basal layer. Proliferation of melanocytes may result in melanocytic lesions ranging from benign freckles and nevi (mole) to malignant melanoma. The diagnosis of melanocytic tumor is one of the most problematic areas in dermatology and diagnostic pathology. Early recognition and correct diagnosis of melanoma is however, challenging due to the wide morphological spectrum. The purpose of this study is to evaluate the clinicopathological spectrum of cutaneous melanocytic lesions. Methods- 63 biopsy specimens of clinically diagnosed cutaneous melanocytic lesios were reviewed histologically in the Department of Pathology at SMS Medical College, Jaipur (Rajasthan) . In this Resultsstudy benign lesions 42( 66.3 %) were more than malignant lesions 21 (33.7%). Among benign lesions most common was intradermal nevus 26 (41.3%) with female preponderance. In malignant lesions most common was conventional melanoma 13 cases with male preponderance .Most common site for benign were forearm ,trunk , face and for malignant was foot. In wide local excised specimens most common Clark's level of invasion was III. In this study 85.7 % clinically diagnosed cases well correlat Conclusion and Interpretation- ed with histopathological diagnosis while 14.3% histopathological diagnosis had varied clinical presentation. The spectrum of various cutaneous melanocytic lesions in relation with different parameters is well documented. This study will facilitate pathological reporting and aid clinicians to make focused investigation and plan appropriate treatment.

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