DOI: 10.4103/ijdt.ijdt_51_25 ISSN: 2949-8457

A Cross-sectional Study to Assess the Prevalence of Diabetic Peripheral Neuropathy Using Michigan Neuropathy Screening Instrument among Indian Patients with Diabetes

Subhash Wangnoo, Samiran Das, Mahesh D. Mruthyunjaya, Amit Asalkar, Beatrice Anne, Subrata Chakrabarti, Manoj Kumar Agrawal, Gayatri Ghanekar, Parth Jethwani, Manjunath Dodamani, Vishwanath Shivanappanavar, Subir Chandra Swar, Dhrumil Patel, Manish Agrawal, Hiren Prajapati
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Abstract

Background:

There is a high burden of diabetes associated complication-diabetic peripheral neuropathy (DPN). This study aimed to assess the prevalence of DPN (ADAPT) among type 2 diabetes mellitus patients visiting outpatient departments at diabetes centers across India.

Materials and Methods:

ADAPT was a multicenter, observational, cross-sectional study in which type 2 diabetes mellitus (T2DM) patients visiting diabetes clinics were screened for DPN. Eligible diabetes patients were asked to complete the Michigan Neuropathy Screening Instrument (MNSI) questionnaires for screening of DPN. Multivariable logistic regression was performed to identify independent predictors of DPN. Data were analyzed with Epi Info 7 software and Python (statsmodels library).

Results:

A total of 13,745 patients were analyzed. The overall prevalence of DPN was 63.3% ( n = 8695) in T2DM patients with MNSI score ≥7. Among the DPN patients, Tier 1 cities had a high burden (38%), followed by Tier 2 (35%) and Tier 3 cities (27%). Multivariable logistic regression identified hemoglobin A1c (odds ratio [OR]: 1.24), dyslipidemia (OR: 1.58), thyroid disorder (OR: 1.54), combined OAD + Insulin treatment (OR: 1.65), current alcohol use (OR: 1.52), coronary artery disease (OR: 1.24), duration of diabetes (OR: 1.05), age (OR: 1.01), and hypertension (OR: 1.09) as independent predictors of DPN (all P < 0.05).

Conclusion:

ADAPT study shows that 6 out of 10 type 2 diabetes patients suffered from DPN. This indicates the need to routinely screen T2DM patients for early detection of DPN.

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