Shambhavi Kulkarni, A. N. Dattatri, Harish Kulkarni

A CROSS-SECTIONAL STUDY OF ADVERSE DRUG REACTIONS TO ANTIRETROVIRAL THERAPY IN PEDIATRIC PATIENTS IN A TERTIARY CARE HOSPITAL

  • General Medicine
  • General Earth and Planetary Sciences
  • General Environmental Science
  • General Medicine
  • Ocean Engineering
  • General Medicine
  • General Medicine
  • General Medicine
  • General Medicine
  • General Earth and Planetary Sciences
  • General Environmental Science
  • General Medicine
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Aim of the study: To assess the adverse drug reactions (ADRs) to antiretroviral therapy (ART) among paediatric patients of HIV. Materials and methods: After obtaining approval from the institutional ethics committee, a cross-sectional, observational study was conducted among 134 HIV/AIDS patients aged < 15 years. Patients who were on ART since 6 months were included in the study. Written and informed consent was obtained from the participant or the guardian. The study was conducted in the Department of Paediatrics, KIMS, Hubballi. The data was collected by self report by the care giver or the child regarding treatment adherence over the past month and ADRs experienced by them during the course of therapy, using a questionnaire. Condentiality of patients was maintained throughout and after the study. Results: The most common time of occurrence of ADR was within the rst 2 months of initiation of ART and the most common ADR was nausea and vomiting. 76.9% ADRs were 'probable' on Naranjo causality assessment and 92.3% were mild in nature. A statistically signicant association was seen between adherence and ADRs. Occurrence of ADRs was higher with patients who were on ZDV+LMV+ EFV regimen. Conclusion: Occurrence of ADRs was seen to signicantly inuence the adherence to ART. As efforts continue in the development of medications with more favourable adverse effect proles, treating physicians must remain aware of new and developing syndromes associated with the use of these drugs.

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