DOI: 10.1002/asia.202400269 ISSN: 1861-4728
A Concise Route to Keto‐Bridged Polyphenols by Photo‐Fries Rearrangement in Flow
Xin-Jie Lin, Chien-Lung Wang, Chi-How Peng, Hsueh-Ju Liu, Yen-Ku Wu- General Chemistry
- Biochemistry
- Organic Chemistry
Described is a new synthetic route to bis(2‐hydroxy‐3,5‐di‐t‐butylphenyl)methanone and its derivatives. The combined esterification/photo‐Fries rearrangement approach enables a modular preparation of keto‐bridged polyphenols. This protecting group‐free process is highly atom‐ and step‐economic, and a scalable production was easily achieved in the continuous‐flow mode.