DOI: 10.1111/jcmm.17875 ISSN: 1582-1838

A concise review on the role of MIR100HG in human disorders

Soudeh Ghafouri‐Fard, Atefeh Harsij, Hossein Farahzadi, Bashdar Mahmud Hussen, Mohammad Taheri, Majid Mokhtari
  • Cell Biology
  • Molecular Medicine


MIR100HG is a long non‐coding RNA (lncRNA) encoded by a locus on chr11:122,028,203‐122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF‐β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in a diversity of cancers in association with clinical outcomes. Moreover, it has a role in the pathophysiology of dilated cardiomyopathy, intervertebral disk degeneration and pulmonary fibrosis. The current study summarizes the role of these lncRNAs in human disorders.

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