Fida Hussain Memon, Kang Inseok, Faheem Ahmed, Wajid Ali, Afaque Manzoor Soomro, Saleem Raza Memon, Kashif Hussain Memon, Kyung Hyun Choi

A Comprehensive Review of Biosensor Integration in Microphysiological Systems for Online Monitoring: Current Challenges and Future Advancements

  • Industrial and Manufacturing Engineering
  • Filtration and Separation
  • Process Chemistry and Technology
  • Biochemistry
  • Chemical Engineering (miscellaneous)
  • Bioengineering
Save to CiteDrive Show PDF

AbstractThe goal of microphysiological systems (MPS) is to replicate the relevant functionality of human organ tissues in in vitro. MPS technology so far has been used to simulate the various human organs and with the help of sensor integration in the MPS systems the biological activities of the organ to be modeled have been translated into data to be analyzed for further considerations. Most standard characterization approaches are intrusive and detrimental, and not feasible for online monitoring of cell cultures. Microfluidic biosensors, for instant, provide non‐invasive on‐line detection of biomarkers and molecules under targeted indicators with a high detection extent, successfully overcoming the limits of existing approaches. Microfluidic biosensors are rapidly being incorporated into MPS and employed for real‐time target identification as a result. In this review the focus is on emerging ways for miniaturizing and embedding biosensing systems in MPS also known as “organ‐on‐chip”. Cutting‐edge microfluidic biosensors are also covered with examples, showing their key benefits in monitoring MPS and highlighting current breakthroughs, before describing the remaining problems and anticipated future improvements in integrated microfluidic biosensors.

Need a simple solution for managing your BibTeX entries? Explore CiteDrive!

  • Web-based, modern reference management
  • Collaborate and share with fellow researchers
  • Integration with Overleaf
  • Comprehensive BibTeX/BibLaTeX support
  • Save articles and websites directly from your browser
  • Search for new articles from a database of tens of millions of references
Try out CiteDrive

More from our Archive