Background & Objectives: Since the past decade, there has been a drastic change in the approach to abdominal surgeries from laparotomy to laparoscopic surgery. Laparoscopy has now become the gold standard in most of the elective abdominal procedures. However, there is still a debate on the use of laparoscopic approach in emergency scenarios such as perforated duodenal ulcer. This study aims to analyze and compare the benets, effectiveness and outcomes of open and laparoscopic surgical treatment of patients with perforated duodenal ulcer. This Prospective Methods: comparative study was conducted on patients in JJM Medical College from October 2020 – September 2022, with sample size of 40 patients, 20 patients undergoing Laparoscopic Graham's Omental patch repair and the other 20 patients undergoing open surgery using Graham's Omental patch repair. The data was analyzed using statistical tests. A p-value of <0.05 was considered statistically signicant. In the present study Results: the mean age of the patients was 41.65 years with 27.5% between 51-60 years. There was no need for conversion to open surgery in the laparoscopic group. Mean operating time was 60 mins and mean hospital stay was 11.7 days for open surgery. Corresponding gures for laparoscopic procedure were 143.8 mins and 7.25 days. Post-operative complications were noted to be lower in the laparoscopy group. The mean time taken to return to work in the open group and laparoscopy group was 19.95 and 9.95 days respectively. This comparati Interpretations & Conclusion: ve study shows a better outcome and lesser morbidity with laparoscopic approach in terms of shorter hospital stay, less post-operative pain, early return to work, lesser wound infections, overall treatment time for the management of duodenal perforation.

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