A comparative study among analytical model and numerical model for studying transdermal drug delivery dynamics

Abstract

This study focusses on one-dimensional (1D) modeling of transient transdermal drug delivery across the epidermis via stratum corneum. In order to mimic in this manuscript how drugs pass through the skin, Fick’s second law has been incorporated as a flow governing equation in microneedles and is solved using a Lattice Boltzmann model. In this study we have assumed that the contact region between skin and drug as a point. To depict this phenomenon, the effect of parameters such as time duration, diffusion coefficient, length of the microneedle, initial drug concentration, cumulative flux and fraction of the drug delivered has been investigated. To validate the present model, the obtained results are compared with an existing analytical results.