A CLINICAL COMPARATIVE STUDY OF TWO DIFFERENT DOSES,35MG AND 45MG OF 1% CHLOROPROCAINE IN PATIENTS UNDERGOING LOWER ABDOMINAL, PERINEALAND LOWER LIMB SURGERIES UNDER SPINALANESTHESIA

Background: The introduction of short-acting local anesthetic agents such as chloroprocaine permits rapid onset of spinal anesthesia for shortduration day-care surgery, offering the advantage of early home discharge. Our study is to compare two different doses, 35mg and 45mg of 1% 2- chloroprocaine in patients undergoing lower abdominal, perineal, and lower limb surgeries under spinal anesthesia. Methods: A prospective randomized controlled study with 100 patients belonging to ASA I and ASA II patients scheduled for elective lower abdominal, lower limb, and perianal surgeries were selected randomly and divided into two groups of 50 each. Group A received 1% chloroprocaine 35mg intrathecally and Group B received 45mg intrathecally. Onset and duration of sensory blockade, Onset, and duration of motor blockade, the highest level of sensory blockade, time for two-segment regression, quality of intraoperative analgesia, hemodynamic parameters, side effects or complications if any were studied Results: The mean time of onset of peak sensory level was 6.74+/- 1.367 and 5.20+/- 1.212 for 2-chloroprocaine 35mg and 45mg respectively. The duration of sensory block achieved with 35mg chloroprocaine was 74.34 +/- 2.639 min and 103.54+/- 5.292 min in the 45mg group. The duration in motor blockade was proportional to the volume of drug injected and was found to be 75.96+/-3.29 min and 95.56+/- 3.92 min in groups A and B respectively. All the patients in both groups achieved a complete degree of motor blockade. The highest level of sensory block achieved in both groups was T6. The time for two-segment regression of sensory block was found to be 44.32+/-2.706 min and 54.16+/- 3.119 min with 35mg and 45mg chloroprocaine respectively. No signicant hemodynamic alteration or complications were noticed. Conclusion: 2-CP can be used as an excellent drug for spinal anesthesia in ambulatory surgeries. The duration of spinal anesthesia, time to resolution of spinal block, and time to recovery of ambulation were dose-related. The dose of 1% 2-chloroprocaine can be titrated according to the desired level and duration of sensory and motor blockade.