DOI: 10.1002/ccr3.7860 ISSN:

A case report of severe hyponatremia secondary to Paxlovid‐induced SIADH

Sarah Mohamed, Mostafa Reda Mostafa, Mohamed Magdi Eid, Yossef Hassan AbdelQadir, Yomna Ali Abdelghafar, Sarya Swed, Bishara Jahshan, Waddah Abd El‐Radi
  • General Medicine

Key Clinical Message

Nirmatrelvir‐ritonavir (Paxlovid) is a brand‐new oral antiviral medication for treating mild to severe COVID‐19. The Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for ritonavir‐nirmatrelvir on December 22, 2021, to treat COVID‐19. We describe a case of mild COVID‐19 infection who developed severe hyponatremia following the administration of Paxlovid. Clinical and laboratory evaluations suggest SIADH, likely secondary to Paxlovid. The potential side effects of this medication still require further study.

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