DOI: 10.1039/d6nr00974c ISSN: 2040-3364
A bidirectional pyroptosis regulation strategy to resolve cardiotoxicity–antitumor efficacy dilemma of doxorubicin
Hanying Xu, Yi Zhang, Hao Guo, Zhong Shao, Shiyong Zhang, Yangyang ChengSelf-crosslinked lipoic acid nanoparticles oppositely regulate pyroptosis in myocardium and tumors during doxorubicin therapy, providing an integrated strategy to reduce doxorubicin-induced cardiotoxicity and strengthen antitumor activity.