DOI: 10.2174/1574885518666230811144105 ISSN:

A behavioral analysis of the combinational effect of Piperine & Bupropion HCl for the treatment of depression

Aparna Gupta, Chandresh Patel, Shashi Verma, Rajat Yadav, Rizwana Bee
  • Pharmacology (medical)
  • General Pharmacology, Toxicology and Pharmaceutics


The goal of this study is to determine that treating depression with Piperine and Bupropion HCl in combination is more successful than with these medicines alone.


-Depression is a mood disorder referred to as the collection of conditions connected with the elevation or lowering of the mood marked by melancholy, loss of interest in activities, with little or no social life. Despite the enormous amount of research, efficient treatment of depression is still one of the most desired aspects of managing depression.


This study is focused on establishing the effectiveness of combinational therapy through animal behavioral models.


The study was initiated by acclimatizing animals for one week in conventional laboratory settings. Depression was induced in animals through the forced swim method. Animal behavioral models were utilized to investigate the efficacy of the drug combination for the treatment of depression.


Positive results were reported for the group treated with the drug combination and were significant (p < 0.05) to every other group that participated in the study. No mortality was found in any of the study groups.


This study supports the efficacy of combinational therapy of Piperine and Bupropion HCl for treating depression.

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