68Ga prostate-specific membrane antigen PET/computed tomography in benign and malignant prostatic lesions: a study of maximum standardized uptake value and uptake patterns with clinicopathological correlation
Prathamesh Mangale, Archi Agrawal, Sayak Choudhury, Gagan Prakash, Vedang Murthy, Amit Joshi, Santosh Menon, Mahendra Pal, Venkatesh RangarajanAim
Assessment of maximum standardized uptake value (SUV max ) values and patterns of uptake on 68 Ga prostate-specific membrane antigen (PSMA) PET/computed tomography (CT) in benign and malignant prostatic lesions.
Methods
Retrospective observational study of prostate cancer patients referred for 68 Ga-PSMA PET/CT for initial staging. SUV max of the prostatic lesion was correlated with risk category, International Society of Urological Pathology (ISUP) grade groups, prostate-specific antigen (PSA), and Gleason score. Uptake patterns across risk categories were also evaluated.
Results
A total of 325 subjects were included (14 benign and 311 malignant). Median SUV
max
of benign lesions was 8.29. Grade groups 4 and 5 showed significantly higher median SUV
max
values (26.42 and 26.55) than other grade groups. SUV
max
correlated positively with ISUP grade group, Gleason score, and serum PSA (all
Conclusion
SUV max differentiates high-risk from low‐ and intermediate-risk prostate cancer and may serve as a noninvasive independent prognostic marker. Intraprostatic uptake pattern has no significant role in lesion categorization.